Thirteen people were treated for injuries, the New York Fire Department said on Twitter.
The New York Police Department closed off the area but aren't treating it as a terrorist incident.
A Reuters witness said at least 10 people were being treated for injuries on the ground after the collision around noon at the Midtown Manhattan tourist site.
The vehicle was a red sedan and CBS New York Television said the driver had been removed. Witnesses said the motorist had driven against traffic and onto the pavement striking pedestrians.
The car crashed into a pole and came to rest at 45th Street and Broadway.
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